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In addition to levodopa, DA receptor agonistssuch as pramipexole, ropinirole, and rotigotinecan also be utilized in the treatment of PD, particularly for early-stage patients or in conjunction with levodopa to delay the onset of motor complications ( In addition to directly supplementing or activating DA receptors, prolonging the duration of endogenous DA action represents another important strategy

Herster F

Persistent activation of this pathway, potentially driven by chronic cellular stress, unresolved DNA damage, or microbial dysbiosis, can sustain a pro-inflammatory and pro-fibrotic renal microenvironment [37]

Despite a plethora of primary physiological functions, several studies have shown an imbalance between arginase and NOS activity in oxidative stress conditions

Cochrane Database System Rev 4(4):CD008208