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As observed in the case of the whole biosynthetic pathway, yeast strains engineered to incorporate GSTs unrelated to anthocyanin biosynthesis did not produce any of the anthocyanidin-3- O -glucosides (Fig

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6c), whereas combined perturbation of PHF3 and DIDO showed the strongest growth defect, particularly when DIDO Full KO was combined with PHF3 KO (Fig