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v3 Integrin v3 integrin is potentially a key player in regulating outflow through the TM/SC and is found throughout the TM/SC (Gagen et al., 2013

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Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis

When comparing all tumours with GC excess (n=15) to the remaining inactive and non-GC-secreting tumours (N=28), LEF-1 expression was significantly higher in GC-producing tumours (comprising GC and GCA) compared to non-GC-producing tumours with a median H-score of 70 ( Figure 6D ), but we did not observe a significant difference for CTNNB1 ( Figure 6E ) or GR ( Figure 6F ) expression in our dataset, respectively