l-carnitine's effect on metabolism Role of carnitine in disease | Nutrition & Mechanism of L-carnitine deficiency in

References Acetyllevocarnitine Hydrochloride for the Treatment of Diabetic Peripheral Neuropathy: A Phase 3 Randomized Clinical Trial in China

Abbreviations AKT: Protein kinase B BMI: Body mass index CFA: Cross-sectional fiber area Cox-2: Cytochrome c oxidase subunit II CPTI- II: Carnitine palmityl transferase I and II FOXO: Forkhead box O transcription factor family FOXO3a: Forkhead box O transcription factor 3a GI: Gastrointestinal GM: Gastrocnemius muscle HE: Hematoxylin and eosin HMB: -Hydroxy--methylbutyrate IGF1: Insulin like growth factor 1 IL-1: Interleukin-1 IL-6: Interleukin-6 LC: L-carnitine MaFbx: Muscle atrophy F-box protein MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin MuRF1: Muscle RING-type E3 ubiquitin ligase 1 NF-B: Nuclear factor NF-kappa-B PIF: Proteolysis-inducing factor TGF: Transforming growth factor beta TNF-: Tumor Necrosis Factor TWEAK: TNF-like weak inducer of apoptosis References Siegel RL, Miller KD, Jemal A

, L-Carnitine 46 ,

PECAM-1 stabilizes blood-brain barrier integrity and favors paracellular T-cell diapedesis across the bloodbrain barrier during neuroinflammation

The anti-inflammatory and anti-fibrotic properties of L-carnitine underscore its potential to halt MASLD progression to advanced stages