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Neuronal Signaling 5:NS20210008

ClinicalTrials.gov was queried to identify registered or ongoing trials

PQQ, a vitamin-like compound found in fruits and vegetables, is a powerful antioxidant that protects nerve cells, supports the mitochondria, enhances memory, and lowers inflammation

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As shown in Figure S7, key differences in the binding modes of non-cyclic ligand 7a and cyclic ligands 7b 7i were revealed through analysis of their intermolecular interaction profiles, with 7a forming numerous but low-frequency contacts - likely due to its flexible warhead - while the more rigid cyclic ligands engaged in fewer but higher-frequency interactions, indicating slightly greater binding specificity and complex stability