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The multifaceted status of DRE patients underscores the emphasis on non-pharmacological options, and therapies that target multiple mechanisms are likely to be more effective to treat DRE ( Clinical studies show that both modalities (VNS and KD) lead to a seizure frequency reduction (SFR) by at least 50% in half of the DRE patients

An indirect NRF2 activator through Bach1 derepression was developed to overcome these problems and relieved MPTP-induced neurodegeneration and associated oxidative stress [94]