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ER stress can also be caused by other mechanisms such as inhibition of ERG transport, which results in accumulation of secretory proteins within the ER (Hyer-Hansen and Jttel, As it is known, mutations of SOD1 in transgenic rats or mice induced motor neuron disease (Gurney, G93A causes protein aggregation inducing cellular damage (Bendotti and Carr, SOD1 as neuromodulator Many studies pointed out that muscarinic receptors are widely expressed in the central nervous system controlling several neuronal functions

They have a role in antioxidant defense, but on the other hand, Grxs are able to bind and deliver iron-sulfur clusters, also involved in the deglutathionylation process and in the regeneration of multiple enzymes, such as peroxiredoxins and methionine sulfoxide reductases (Rouhier et al

Results Reduced inflammation in Mda5 -/- HSCs and bone marrow serum Since activation of MDA5 induces a type-I IFN response and the secretion of pro-inflammatory cytokines, we isolated bone marrow serum from aged (18 to 24 months old) wild-type WT (or Mda5 +/+ hereafter WT) and Ifih1 -knockout mice (also known as Mda5

doi: 10.1016/S0140-6736(24)00876-6

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