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In both C408S-containing structures, the Fe(II)-C201 S (or O ) distance is elongated relative to wild-type CstB, to 3.6-3.7 , while in the C201S mutant, the S201 O has rotated away from the Fe(II), adopting a distinct rotamer (5.2 away)

Machine learning and big data analytics will enable the development of novel digital biomarkers and sensor-based functional outcomes based on rich streams of sensor data which may provide more sensitive measures of treatment impact

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Singh, L.S

The establishment of changes in synaptic strength involves both the pre and post synaptic mechanisms