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Joraholmen, M

Nature 394 , 897901 (1998)

401-429 [online] Available at: Selhub, J., Jacques, P.F., Bostom, A.G., Wilson, P.W

Rice, Chunping Wang, Bo Chen, Lawrence Carin, Arturo Suarez, Robert P

Despite B cells playing a key role in the SLE pathogenesis, B cell depletion with current monoclonal antibodies such as belimumab fails to achieve symptom remission in many lupus patients ( Initially, studies in murine models of SLE showed efficacy of anti-CD19 CAR-T therapy in B-cell depletion and reduction of disease progression ( Long-term follow-up of 8 SLE patients, including the previously mentioned patient, demonstrated significant progress with CD19 CAR-T therapy