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Conversely, LPS disrupts the BBB by directly damaging endothelial cells, activating TLR4 to trigger NF-B expression and systemic inflammation, which increases tight junction permeability, induces pericyte degeneration and endothelial apoptosis, and promotes astrocyte foot process phagocytosis (Zhao and Lukiw, 2018

During an in vitro study, it was found to protect against glutamate-induced excitotoxicity (Kobayashi 2000)

Shaking creates air bubbles and can cause protein aggregation effectively denaturing the peptide at the foam interface

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The blood biochemistry analysis was performed with Hitachi Automatic Biochemical Analyzer 7100