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It also affects the central nervous system by increasing gamma-aminobutyric acid (GABA) levels, a neurotransmitter that reduces brain overactivity and promotes relaxation

Returning too early can raise recurrence risk, while waiting too long can slow conditioning and performance

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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

Nivolumab versus chemotherapy in patients with advanced melanoma who p rogressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, c ontrolled, open-label, phase 3 trial