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This in vitro potency translated into in vivo efficacy, where a single dose of the BsADC (5 mg/kg) achieved 85% tumor growth inhibition in a BT-474 xenograft model, compared to 45% inhibition by the conventional ADC at the same dose

These results indicate full integration of BUD13 into the activated spliceosome

Boullata J (2005) Natural health product interactions with medication

PBANKA_0916000 encodes an essential digestive vacuole protein related to the chloroquine resistance transporter How mutants behave in the homing screen may be confounded by factors other than gene function, such as the efficiency of gRNAs, how much transcript or protein a zygote inherits from the female parent and how fast these turn over

Jones JB, Song JJ, Hempen PM, Parmigiani G, Hruban RH, Kern SE