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At elevated concentrations (510 M), curcumin directly binds to the DNA-binding domain of the NF-B p65 subunit (Kd = 2.3 nM) and the adenosine triphosphate (ATP)pocket of IKK (G = 7.6 kcal/mol), exerting steric hindrance to impair their functions (Wang et al., 2018

PMID: 30989213 J Agric Food ChemFunctional Characterization of UGT90A2 and Its Application in One-Pot Synthesis of Quercetin 3,4'-di- O--d-glucoside

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Further studies are required to better understand how GGT1, other GGT family members and uncharacterized proteins with GGT activity contribute to extracellular GSH catabolism