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These are metformin and insulin sensitizing drugs (thiazolidinediones)

Dysregulation of the HPA axis is a well-established feature of depression, and the interplay between stress, alcohol use, and mood disorders underscores the need for a comprehensive understanding of these mechanisms (Stephens and Wand 2012)

Already in the 1960s Carlton reported that cuprizone ingestion in mice led to enlargement and hyperplasia of astroglia in brain regions that showed signs of cuprizone-induced demyelination and that astrocytosis preceded loss of myelin (Carlton, 1967)