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NAD+ and NADH are functionally oppositeNAD+ oxidizes substrates (accepts electrons) while NADH reduces substrates (donates electrons), and the ratio between them governs cellular energy production and sirtuin-mediated longevity pathways

Ferroptosis is defined by the preservation of functional cytoplasmic membranes, increased mitochondrial membrane density, decreased or absent cristae, increased release of oxidized PUFAs, elevated cytoplasmic levels of lipid ROS, and the process can be inhibited by iron chelators (Yang and Stockwell, 2008

doi: 10.1038/s41590-023-01601-2 36 SteinSRRamelliSCGrazioliAChungJ-YSinghMYindaCKet al

Conclusion In conclusion, our in vivo studies indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide