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Introduction Interstitial cystitis/Painful bladder syndrome (IC/PBS) is chronic discomfort of the bladder wall, presenting with symptoms such as urinary frequency, urgency, and severe pelvic or suprapubic pain

PMID 35410603

[0156] Embodiment 149: The immunoconjugate of embodiment 148, wherein the drug comprises a duocarmycin, selected from the group consisting of duocarmycin A, duocarmycin B l, duocarmycin B2, duocarmycin CI, duocarmycin C2, duocarmycin D, duocarmycin SA, Cyclopropylbenzoindole duocarmycin (CC-1065), Centanamycin, Rachelmycin, Adozelesin, Bizelesin, and Carzelesin

4MSOB GSL is the predominant aliphatic GSL in wild-type and CYP79A2 KI plants, but is not present in myb28myb29 KO and myb28myb29 cyp79b2cyp79b3 KO plants, while indolic GSLs, such as indolyl-3-methyl (I3M) GSL, are present in wild-type, myb28myb29 KO, and CYP79A2 KI plants (Fig

Patients with arthritic and rheumatic diseases often experience chronic pain, inflammation, and fatigue, which can be alleviated through targeted IV therapy