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The pain message from the skin goes to the spinal cord and sends a signal right away to the muscle to contract

Proteins are the big machines doing heavy lifting Peptides are the tiny command buttons signaling to those machines when and how to work If proteins are hardware, Peptides are the software instructions

This suggests that activation of PXR by some drugs may be responsible for the acceleration of vitamin D breakdown through increasing CYP3A4 and CYP24, leading to vitamin D deficiency and, eventually, to bone loss [1]

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doi: 10.1111/j.1365-3040.2009.01944.x 125 MittlerR