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Without these structural reforms, the field risks mistaking molecular promise for therapeutic progress and stalling the development of interventions that could meaningfully alter the trajectory of neurodegenerative disease

11,12 The 1990s introduced crucial discoveries in endoplasmic reticulum (ER) stress signaling and unfolded protein response (UPR) pathways, establishing ER proteostasis as a cornerstone of metabolic and neurodegenerative disease biology

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