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Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

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Genetic variants such as methylenetetrahydrofolate reductase (MTHFR) T and catechol-O-methyltransferase (COMT) Val alleles are linked to impaired folate/homocysteine metabolism, endothelial dysfunction, and poorer executive functions in schizophrenia, supporting a genetic contribution to vascular and cognitive deficits (173)

Artificial intelligence and machine learning could also be leveraged to optimize nanoparticle design, predict biodistribution, and personalize treatment regimens