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Moreover, studies indicate that PDAC cells, through TGF-1 and lysophosphatidic acid (LPA) signaling, induce mPSCs to adopt a more myCAF-like phenotype, which then secretes type I collagen to suppress tumor dissemination [41, 68, 69]

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306 Exposure to arsenic can result in toxicity, primarily caused by the generation of reactive oxygen intermediates during its redox cycling and metabolic activation