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IGF-1 is a strong stimulator of sebaceous lipogenesis and acne pathogenesis has been linked to elevated IIS with consecutive nuclear FoxO deficiency [16, 17]

doi:10.3390/ANTIOX12020393 Sun Y, Liu W, Zhang H, et al

Unlike PDT, limited by shallow light penetration, or SDT, which suffers from relatively low sonosensitizer-to-ROS conversion efficiency despite improved depth access, the RT/RDT strategy leverages X-rays exceptional tissue penetration and strong ionizing capacity