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The multisystem effects of hypermobile Ehlers Danlos Syndrome The multisystem effects of hEDS include: 14 Musculoskeletal joint pain and instability, tendinopathy, weakness, reduced bone density Neurological/Neurodevelopmental proprioceptive, coordination, sensory deficits, neuralgia, Autistic Spectrum Disorder, Attention Deficit Hyperactivity Disorder Autonomic nervous system cardiac dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), Raynauds cold hands and feet Dermatological hyperextensible skin, easy bruising, poor healing, scarring Gastrointestinal Gastric reflux, pain, slow transit, constipation, irritable bowel Cardiorespiratory Mitral valve prolapse, aneurysms, varicose veins, asthma-like symptoms due to floppy airways Mental health - Anxiety, depression Uro-genital Urinary incontinence, prolapses, painful periods Immunological Mast cell activation syndrome, rashes and sensitivities Multisystemic widespread pain, chronic fatigue and sleeping difficulties

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J Fluoresc 30(6):14391446

Electrophysiological studies have demonstrated an increased spontaneous firing rate among cortical auditory neurons, which is further amplified in the presence of external auditory stimuli

KLOW Blend Research Protocols & Administration Dosing in Published Research Research investigations of individual components have employed various dosing strategies that inform potential combination approaches