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Without this comparison, distinguishing true intervention effects from natural variation may not be impossible

By contrast, xenoestrogens commonly found in polymers of plastic polycarbonates, such as mineral water bottles and lacquer coating in food cans, can act as endocrine disruptors that significantly alter estrogen-mediated signaling pathways (Wagner and Oehlmann, 2009)

NAD temporarily alters brain signaling, the autonomic nervous system, and neurotransmitters that also regulate gut activity, causing temporary unease

Given that BSO possesses non-specific pharmacological activities, the authors concluded that this effect was independent of the inhibition of GSH biosynthesis 15