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High-risk groups include older adults, vegetarians, vegans, people with gastrointestinal disorders like Crohns disease, and individuals who have undergone weight-loss surgery

demonstrated that IgG, IgA, and IgE antibody levels rise with disease intensity, suggesting mast cell involvement

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Dysfunctions of the orexins are related to both obesity and sleep disorders such as narcolepsy due to the overstimulation of the orexin receptors