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Following treatment-induced stress or destruction, tumor cells release DAMPs such as calreticulin (CRT), 33 high mobility group box 1 (HMGB1), 34 and adenosine triphosphate (ATP), 35 which are recognized by APCs, especially dendritic cells (DCs), via PRRs, 36 leading to antigen uptake, maturation, and cross-presentation to T cells

GST enzymes are essential in detoxifying endogenous or exogenous toxic compounds by catalyzing the conjugation of the nucleophilic thiol group from reduced GSH to co-substrates possessing an electrophilic center

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Take first dose in the morning or before cardio, second dose before lunch or workouts, and final dose post workout

doi: 10.1097/NMD.0000000000000425 145 PfaffensellerB.Da Silva MagalhesP