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demonstrated that the Drp1 inhibitor Mdivi-1 effectively inhibited IL-1-induced mitochondrial fragmentation, mtROS burst, and caspase-3 activation, reducing chondrocyte apoptosis (83)

Methods Ethical statement The animal experiments were compliant with the ethical guidelines of the Institutional Animal Care and Use Committees of Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (approval research project number: ECSIOC_2023-23)

PMID: 41978696 Life Sci Cisplatin transported by COX17 induces cochlear damage by binding Myosin IIA to regulate cell pyroptosis induced by mitochondrial dysfunction

doi: 10.1016/j.ccell.2022.08.014