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The schematic in Figure 2C captures the sequential progression of hallmark AD features, such as amyloid plaques, tau tangles, neuronal loss, gliosis, synaptic degeneration, and cognitive decline

Corts-Albornoz MC, Garca-Guqueta DP, Velez-van-Meerbeke A, Talero-Gutirrez C

Classification of distinct tendinopathy subtypes for precision therapeutics

Watchorn, J., Stuart, S., Burns, D

Additionally, the genetic defect impairs normal neural crest cell migration into the branchial arches, causing craniofacial anomalies and severe conotruncal cardiac defects (interrupted aortic arch) that may require immediate palliative interventions like balloon septostomy