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The outer layer contains a variety of microorganisms, the inner layer is virtually free of microorganisms, and there is only a single layer in the small intestine in which the PAN cells located in the small intestine secrete antimicrobial peptides, defensins and other immunomodulatory proteins that limit the attack of bacteria and harmful substances on the intestinal epithelial cells (Mu et al., 2017

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Cisplatin-resistant ovarian cancer cells displayed reduced oxphos and increased dependency on glucose compared to their cisplatin-sensitive counterpart (Pandit et al., 2021)

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Meanwhile, this combination regimen could increase the accumulation of reactive oxygen species (ROS), upregulate the expression of apoptosis-related factors, and reduce the mitochondrial membrane potential (MMP)