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Y.et al (2019)

Additionally, the harsh acidic environment of the stomach and/or dysfunctions in R-proteins (haptocorrins) that protect B12 in the stomach, and potential degradation by gastric enzymes can compromise the stability and bioavailability of oral B12 supplements

F h (liver) F h is what survives the first pass effect (E h ), hence F h = 1 E h E h = CL / Q h (CL: hepatic clearance

P.RobinsonN

While the role of lipid-uptake by MM cells and any functional consequences is unclear, recent studies demonstrate that myeloma-associated bone marrow adipocytes undergo lipolysis, associated with the uptake of secreted free fatty acids by adjacent MM cells (69, 70, 72)