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PMID: 32017040 J Med ChemIntegrated Strategic Design and In Situ Click Chemistry Approach to Rapid Discovery of Novel Potent Covalent TEAD Inhibitors

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The structure shows the position of the essential zinc atom that is involved in catalysis of class I/II HDAC

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Cell Mol Gastroenterol Hepatol 12(1):354377 Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

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d : FT282, n = 8 technical replicates representative from 3 independent experiments

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