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CPT1 catalyzes the transfer of the acyl group from Coenzyme A to a molecule of L-carnitine, creating a newly formed complex called acylcarnitine

However, the hepatic extraction ratio for morphine is morphine clearance (60 L/h/70 kg) divided by hepatic blood flow (90 L/h/70 kg) or 0.67

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2023 Jun;33(6):3956-3960

This more severe kidney injury may reflect early extensive tubular dysfunction in the distal renal tubule or damage at AKI occurrence, further amplifying the discrepancy to milder forms of AKI or those without clinical kidney injury