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The University of Vermont Institutional Animal Care and Use Committee (IACUC) approved all animal work (IACUC no

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HDAC4 is the specific deacetylase responsible for mediating the deacetylation of GSDMD, while the catalytic subunits of protein phosphatase 1 (PP1), namely PP1 and PP1, dephosphorylate and inactivate HDAC4, thereby promoting acetylation-mediated pyroptosis of GSDMD [286]

, Lucas, R