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Serotonergic deficits in the hippocampus may also play a role, as serotonin re-uptake (5-HTT) sites are preserved or upregulated in aggressive compared to non-aggressive patients and 5-hydroxyindoleacetic acid (5-HIAA) levels inversely correlate with agitation scores (Lai et al., 2011

[2] Copper also appears to be vital in iron metabolism and embryonic development, potentially essential for most metabolic reactions that occur in fetal development, oxygenation, and other biological processes

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Furthermore, ROS inhibits protein activity by oxidizing unsaturated or sulphur bonds, resulting in protein impairment

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