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High-fat diets (HFD) in mice have also been shown to reduce beneficial bacteria such as Bifidobacteria , which improve mucosal barrier function, reducing gut permeability and inflammation (72)

Ketamine, a dissociative anesthetic, works along the glutamate pathway and has shown promise as a potential treatment for severe depression in small doses.80 In nootropic supplements, caffeine, cocoa, theobromine, and L-theanine may influence glutamate

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Of note, a growing number of studies support mitochondrial metabolism of LAC as a common culprit underlying psychiatric and neurodegenerative diseases such as MDD and AD as well as obesity, making it important to further understand mechanisms for the development of aberrant mitochondrial metabolism of LAC

It may boost energy levels as it increases the amount of fuel availability that the heart requires to function