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doi: 10.3389/fmicb.2023.1204122 43 GaoL.LiuY.YeL.LiangS.LinJ.ZengJ.et al

Based on this mechanistic insight, we hypothesized that co-targeting both pathways would overcome resistance

dsDNA can form PYD domain helical filament with AIM 2, nucleate ASC, mediate the activation of caspase-1, and induce the pyroptosis process or release active IL-1 and IL-18, which have great inflammatory potential (174)