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W.KntgenF.et al (1999)

Thus, consuming excess beer does not only prevent the liver from processing existing estrogens and but also adds additional estrogen components

They could lead to sequestration of CoASH in the mitochondrial matrix and cause potential harm to biological cycles

Bioavailability: Numerous phytochemicals exhibit limited bioavailability, implying they are inadequately absorbed and processed within the body, thereby constraining their capacity to reach the damaged brain tissue effectively