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DNA damage and cancer immunotherapy: A STING in the tale

Kouskouti A, Scheer E, Staub A, Tora L, Talianidis I

LAG3 is an important inhibitory immune checkpoint that, by binding to MHC II molecules, suppresses T cell activation and proliferation ( + T cells into the tumor microenvironment, but also promotes T cell exhaustion by downregulating the secretion of key cytokines, such as IFN- ( Using the TIDE algorithm, our study predicted immunotherapy outcomes and found that patients in the high-risk group had higher overall TIDE and immune exclusion scores, with significantly lower response and benefit rates compared to the low-risk group

Intra-peritoneal injection of thioredoxin in mice decreases pulmonary neutrophil inflammation and decreases the severity of poly(I:C)-induced emphysema

Table 1 Overview of cell death types