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64 A large double-blind, randomized, placebo-controlled trial in detoxified patients with AUD from 11 sites in 4 European countries was performed (randomized to 6 months of treatment with SMO at 3.33.9 g/d vs placebo, followed by a 6-month medication-free period) showed efficacy in cumulative abstinence duration during the 6-month treatment period with a sustained effect during the 6-month medication-free period

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372 Furthermore, lactate can increase the expression or function of DNA repair-related genes, increasing the capacity of tumor cells to respond to chemotherapy-induced DNA damage