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Therefore, it is possible that the erythrocyte index may not reflect the brain index, but could reflect the uptake of DHA by other peripheral tissue that acquire DHA through non-Mfsd2a pathways, including uptake of free FA through diffusion, and the receptor-mediated uptake of lipoproteins

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One major mediator of this event is transforming growth factor-beta (TGF-), which is secreted by the tumor stroma and participates in a paracrine signaling loop with tumor cells [19]

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This characteristic has allowed researchers to study its systemic biological effects across multiple experimental models