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Oxidative stress inhibition via apocynin prevents medullary respiratory neurodegeneration and respiratory pattern dysfunction in a 6-hydroxydopamine animal model of Parkinsons disease

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Increased ROS production has important consequences with respect to signaling by the soluble guanylate cyclase and the cyclic guanosine monophosphate-dependent kinase I, whose activity and expression has been shown to be regulated in a redox-sensitive manner