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This event drives a rapid influx of FFAs into mitochondria, exacerbating ROS generation and facilitating the production of additional 4-HNE ( Rab7, a small GTPase localized at the contact sites between LDs and lysosomes, undergoes phosphorylation at tyrosine 183 (Tyr183), enabling the recruitment of its effector protein RILP

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Most healthy puppies do best with a complete, growth-appropriate diet and good preventive care rather than targeted antioxidant supplementation

chloroquine) induce lysosomal stress and, consequently, provoke transcription factor EB (TFEB) nuclear translocation [48], which could drive expression of autophagy genes and induce autophagy

Model 2 was additionally adjusted for smoking status (never, ever, or current), physical activity (inactive, moderate, or vigorous), body mass index ( 216 nmol/L) (Table 1)