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Nanomedicine 8(4):399-414, 2012

Meanwhile, Tph2 is significantly upregulated in the core region of colorectal cancer tumors, and conditional knockout of Tph2 in intestinal epithelial cells markedly suppresses tumorigenesis in a murine intestinal cancer model (203)

Reinforcement of UDP-Glucuronic Acid Biosynthesis by Overexpression of the galU and ugd Genes The second option for enhancing hyaluronic acid production was examined by overexpressing the galU and ugd genes encoding glucose-1-phosphate uridylyltransferase and UDP-glucose 6-dehydrogenase, respectively, in strain HA03

Journal for Immunotherapy of Cancer, 4, 36

Engineered Cas9 cleaves the DNA in a sequence-specific mode and creates a specific double-stranded break, so the cell can fill the excised portion with the correct gene sequence