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The carboxyethyl-hydroxychroman metabolite of -tocopherol (-CEHC), carboxychromanols (e.g., 5-carboxymethylbutyl hydroxychroman and the 13-carboxychromanol (13-COOH)) has been identified to have anti-inflammatory properties and display potent bioactivity [105,106]

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In many neurological diseases, comprising both neurodegenerative and neurodevelopmental disorders, alterations in DNA methylation occur at specific genomic regions, including gene promoters, enhancers and CpG islands (25)