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Importantly, siRNA specifically targeting GSTA1 reduced the inhibitory effect of bicyclol on TG level (Figure 5D), indicating the critical role of GSTA1 in mediating the anti-steatosis effect of bicyclol

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Keeping in mind both the explicit purpose of international targets to guide progress, their implicit motivations, and the limitations identified with the current target structure, we propose an alternative methodology for setting international development targets that remain ambitious but are more likely to be achievable