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Once established, the condition often flares during subsequent stressful periods, creating a predictable pattern

Rather than allowing peptide use to remain confined to nonmedical distribution channels, orthopedics should lead the development of standardized perioperative registries and prospective trials using verified formulations, with the goal of determining whether peptide-based therapies can be safely integrated into evidence-based surgical optimization

Breedveld FC, Weisman MH et al (2006): The PREMIER study

Sandhoff disease (GM2 Gangliosidosis with stored GM2 Ganglioside) using targeted enzyme replacement therapy with beta-hexosaminidase A, or substrate inhibition of glucosylceramide synthase using imino sugars (e.g., miglustat (Zavesca marketed by Actelion) = N-butyl- deoxynojirimycin (NB-DNJ))

6a), and the FBP-mediated conformational changes in RCC2 localized to a loop facing the presumed interface for Rac1 interaction (Fig