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Plants such as bracken ferns are problematic while toxicity symptoms vary widely based on dose, duration, and species of affected animals these plants contain thiaminases, and thiamine deficiency has been noted in sheep grazing on the plants in Australia

A few, such as vitamin D or zinc, can help in men with deficiencies, but for most, the effects of over-the-counter testosterone supplements are modest at best

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539,540 Lifestyle interventions, such as a healthy diet, regular physical activity, and smoking cessation, are essential in managing PDPN by improving glycemic control, enhancing nerve function, and reducing pain perception