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Cellular cisplatin accumulation is mainly determined by copper transporter-1, responsible for cisplatin uptake 6,7 and ABCB1 , encoding multidrug-resistant protein 1 (MDR1) involved in increasing platinum-drug export 8,9

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Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

It remains not clear why this surface residue Cys396, located far away from the monomer interaction could lead to monomerization