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Numerous studies have indicated that SASP does not exert solely positive effects [31, 34, 37, 38]

K.DrummondC.AssunoN.VanderborghtB.et al

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For TME-oriented nanoplatforms to move beyond conceptual appeal, they need to be assessed in relation to route of administration, clinical evidence, directness of TME effect, biomarker use, CMC feasibility, safety and value [21, 62, 105]