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These models allow for a systematic investigation of the differential effects of peripheral ApoE isoforms on brain function and AD pathology [85]

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10.1371/journal.pone.0166823 78 LivingstonM

This perspective, supported by the Lancet Commission on Dementia Prevention, Intervention and Care, is grounded in large-scale observational studies linking factors such as low educational attainment, midlife hearing loss, hypertension, obesity, smoking, depression, diabetes, physical inactivity, and social isolation to increased dementia risk (103)