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Similarly, microglial activation with lipopolysaccharide and interferon- has been proposed to activate a microglia-astrocyte-neuron lactate shuttle, particularly in response to excitotoxic stimuli ( FIGURE 2 Astrocyte-neuron metabolic coupling established mostly through MCTs is the underlying molecular mechanism for the astrocyte-neuron lactate shuttle and brain energetic support (Pellerin et al., 1998a

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Point mutations of both Cqd1 and Cqd2 at conserved protein-kinase-like (PKL) or UbiB motif residues disrupted their individual impact on CoQ 6 distribution, indicating that Cqd1 and Cqd2 activities rely on atypical kinase/ATPase activity, though further biochemical work is needed to prove enzymatic activity

doi: 10.7759/cureus.78361 Arif Sehrish